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KMID : 0356919940270030207
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Korean Journal of Anesthesiology
1994 Volume.27 No. 3 p.207 ~ p.213
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The Effect of Intravenous Solu-coref on Vecuronium Induced Muscle Twitch Height in Rabbit
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Abstract
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It is a widespread clinical practice to administer large doses of corticosteroids to patients in cases of shock and or neurosurgery; corticosteroids given intravenously have been proposed and used.
Corticosteroids, when administered in this way during surgery have been implicated in interactions with neuromuscular blocking agents.
Therefore, the effects of Solu-cortef in the neuromuscular blockade produced by vecuronium were studied in vivo on the indirectly stimulated tibialis muscles of the rabbits anethetized with urethane and pentothal sodium.
Control group of rabbits was given intravenous bolus of 0.1 mg/kg vecuronium to produce twitch depression and recovery as recorded by biophysiograph and measured at anterior tibialis muscle twitch in response to common peroneal nerve by double
burst
stimulation (DBS).
First study group (S-1 group) of rabbits was given intravenous bolus of 16 was given. Twitch depression and recovery was measured as control group.
Second study group (S-2 group) of rabbits was given intravenous bolus of 0.1 mg/kg vecuronium during recovery phase, intravenous bolus of 16 mg/kg Solu-cortef was given at DBC ratio 0.5. Statistical analysis was confirmed by oneway ANOVA test,
followed
by Student-Newman-Keuls test.
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